摘要白念珠菌是一种重要的机会致病菌,在人的多个系统或器官与宿主共栖生存,可导致口腔和阴道念珠菌病,在免疫力低下或患严重疾病的患者,可引起系统疾病.由于早期准确诊断系统性念珠菌病存在困难,合适有效的抗真菌药物数量有限,病原体的耐药性增加,导致系统性念珠菌病病死率居高不下.因此,对白念珠菌基因组序列及结构、功能的研究对指导临床的诊断和治疗显得尤为重要.

abstractsCandida albicans, an important opportunistic pathogen, lives as a harmless commensal in multiple organs of human. It can cause oral and vaginal candidiasis, even life-threatening systemic infection in patients with hypoimmunity or malignancy. The mortality rate of candidia infection has been remaining high because of difficulty in early diagnosis of systemic candidiasis, increasing resistance to antifungals and lack of efficient antifungal agents. Therefore, studies on Candida albicans genome structure, sequence and gene function have become more and more important for the guidance on clinical diagnosis and treatment of candidiasis.