摘要信号传导与转录激活因子-3是一种重要的核转录因子,能被白介素-6、表皮生长因子等细胞因子和生长因子激活,参与细胞增殖、存活、转化、迁移等过程.在银屑病皮损中,角质形成细胞中的信号传导与转录激活因子-3几乎都呈激活状态,它能通过调节银屑病相关发病基因和细胞因子的表达,参与角质形成细胞的增殖、分化和存活以及皮损中血管发生,是银屑病发病中重要的信号传导与转录激活因子.

abstractsAs an important nuclear transcription factor, STAT-3 can be activated by numerous cytokines and growth factors such as interleukin (IL)-6, epidermal growth factor (EGF), and so on. STAT-3 participates in cell proliferation, survival, transformation, migration and other biological processes. In psoriatic lesions, almost all STAT-3 is activated in keratinocytes and it takes part in cell proliferation, differentiation and survival of keratinocytes as well as angiogenesis by regulating the expression of psoriasis-related genes and cytokines. STAT-3 is an important signal transduction factor and activator of transcription in the pathogenesis of psoriasis.