摘要报告1例多发性扁平苔藓样角化症伴交界区黑素细胞增生.患者男,83岁.四肢紫红色扁平丘疹、斑块逐渐增多1年,无服药史.组织病理检查显示,表皮角化过度伴角化不全,棘层肥厚,可见坏死的角质形成细胞,基底细胞灶性液化,真皮浅层带状淋巴细胞及少数浆细胞和嗜酸粒细胞浸润,皮损边缘可见日光性黑子样改变.免疫组化染色,苔藓样浸润处Mela-A阳性黑素细胞明显增多,细胞体积大呈星状.

abstractsA case of multiple lichen planus-like keratoses with junctional melanocytic proliferation is reported.An 83-year-old male patient complained of multiple purple red flat papules and plaques on the extremities for 1 year with no medication history.Histopathology examination showed epidermal hyperkeratosis,focal parakeratosis, acanthosis, necrosis of keratinocytes, focal liquefaction of basal cells, bandlike infiltration of lymphocytes, eosinophils and few plasma cells in superficial dernis.Solar lentigo-like pathological changes were observed at the edge of the lesions.Immunohistochemical study revealed an obvious increase in the count of large, star-shaped, Mela-A-positive melanocytes in the lichenoid infiltrates.