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慢性特发性荨麻疹的病因目前尚不明确.研究表明,慢性特发性荨麻疹发病大多有自身免疫机制参与,现已发现了数种与慢性特发性荨麻疹有关的自身抗体,其中抗FcεRI抗体、抗IgE抗体在慢性特发性荨麻疹发病中的地位尤为重要.B淋巴细胞刺激因子可能参与慢性特发性荨麻疹自身抗体的形成.另外,部分慢性特发性荨麻疹患者HLA-Ⅱ类抗原的等位基因DRB1 04频率增加,提示该病发病具有自身免疫遗传基础.

The etiology of chronic idiopathic urticaria (CIU) remains unclear.Recent studies have found that autoimmune mechanisms are involved in the development of CIU in most cases.Several autoantibodies have been found to be associated with CIU.In these autoantibodies,the anti-FcεRI and anti-IgE antibodies appear to play key roles in the pathogenesis of CIU.B lymphocyte stimulator may take part in the production of autoantibodies.Moreover,the frequency of HLA-DRB 1*04 allele is higher in patients with CIU,suggesting a genetic background underlying autoimmune CIU.