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腋臭的病因和发病机制至今尚在研究中.ApoD蛋白可能是腋臭发生分子机制中的核心蛋白,研究表明,顶泌汗腺的分泌物E-3M2H可能借助ApoD蛋白为载体,从体表散发出典型的辛辣气味.ApoD基因自身及其调控因素的差异可能是疾病发生的重要原因之一.在上述过程中,微生物的调控、雄激素及其受体可能在腋臭发病的过程中起了重要作用.腋臭相关基因(ABCC 11)中的单核甘酸多态性(SNP)很可能是患者发病的决定性因素.

The definite etiology and pathogenesis of axillary osmidrosis have not been elucidated yet.ApoD may be the key protein involved in the molecular pathogenesis of axillary osmidrosis.Latest studies have shown that (E)-3-methyl-2-hexenoic acid,which is secreted by apocrine sweat gland and is considered to be the principal axillary odor-related compound,is translocated to the surface of skin with Apo-D as the carrier.The development of axillary osmidrosis may be primarily attributed to the differences in Apo-D gene itself and variation in its regulatory factors.During the above process,the regulation by microorganisms,androgens and their receptors,may play an important role in the pathogenesis of axillary osmidrosis.In addition,the single nucleotide polymorphism (SNP) in the odor-related gene ABCC11 is probably the determinant factor for the development of axillary osmidrosis.