摘要微针是具有不同的材料和形状的针状结构,作用于皮肤形成微米尺寸的小孔,利于药物穿透角质层吸收的一种新型经皮给药系统,伴随着微电子工业和材料学的发展而发展.传统的基于微针的经皮胶原蛋白诱导疗法,在痤疮、皮肤色素沉着、瘢痕、皱纹以及改善肤色等美容治疗方面发挥了作用.近年来,微针辅助治疗皮肤肿瘤也有新的研究进展.由于其独特的经皮给药模式、高安全性和便携性,对于某些顽固难治的浅表性皮肤疾病,微针结合外用药物具有广阔的临床应用前景.

abstractsMicroneedles are a new transdermal drug delivery system(TDDS)derived from microelectro-mechanical systems.The needle-like structures in different materials and shapes,which have improved with the development of microelectronics industry and material science,can remarkably increase the permeability of drugs by forming minimal pores in stratum corneum.The traditional microneedle-based percutaneous collagen induction therapy is currently used to treat acne,as well as to improve cutaneous pigmentation,scars,wrinkles and skin tone.Recently,some advances have been achieved in the treatment of superficial skin tumors with microneedles.Due to their unique transdermal delivery mode,high security and portability,microneedles combined with topical medications will have a wide range of clinical applications in the treatment of some intractable superficial skin diseases.