摘要血管生成拟态是近年发现的一种新的恶性肿瘤血供方式,由肿瘤细胞自身发生基因逆转,通过重塑、变形及与细胞外基质相互作用,形成管道系统,为恶性肿瘤如恶性黑素瘤供应血液及营养.恶性黑素瘤血管生成拟态的分子调节机制十分复杂且不完全清楚,其调节相关因子,如:血管内皮钙黏蛋白、层粘连蛋白-5y2、磷酸肌醇3激酶、基质金属蛋白酶等,通过其各自的调节途径参与恶性黑素瘤血管生成拟态的形成,且多数调节相关因子对恶性黑素瘤的生物学行为起促进作用,影响患者预后.

abstractsVasculogenic mimicry is a sort of novel blood-supplying pattern in malignant tumors,in which,some tumor cells experience gene reversion,reconstitution and deformation,then interact with extracellular matrix,and finally form channels to supply blood and nutrients to malignant tumors such as melanoma.The molecular mechanism underlying the regulation of vasculogenic mimicry is complicated and unclear in malignant melanoma.Many regulatory proteins,such as vascular endothelial cadherin,laminin-5γ2,phosphoinositide 3-kinase and matrix metalloproteinases,participate in the formation of vasculogenic mimicry in malignant melanoma via their respective pathways,and most of them play a positive role in the biological behavior of malignant melanoma and affect the prognosis of patients.