摘要银屑病是一种T细胞介导的以角质形成细胞过度增殖为特征的慢性炎症性皮肤病,其发病机制尚未阐明,可能是由遗传因素、免疫因素、环境因素、肥胖等多种因素互相作用的多基因遗传病.近来,临床研究发现,银屑病伴发肥胖的比例增高,针对肥胖治疗后有助于银屑病好转,提示肥胖与银屑病密切相关.瘦素是参与机体代谢的脂肪因子,以往研究表明,瘦素与其受体在银屑病皮损中高表达,瘦素可能与银屑病的表皮过度增生相关,提示瘦素与银屑病和肥胖可能存在内在分子联系.

abstractsPsoriasis is a chronic T cell-mediated inflammatory skin disease characterized by keratinocyte hyperproliferation.At present,the pathogenesis is not yet clarified.It is considered that psoriasis is a genetic disease resulting from the interaction between genetic factors,immunological factors,environmental factors,obesity,and so on.Recently,clinical observations have suggested that obesity is more prevalent in psoriatic patients than in healthy individuals,and treating obesity may improve psoriasis,hinting that obesity is closely correlated with psoriasis.Previous studies revealed that leptin (an adipokine modulating body metabolism) and its receptor were highly expressed in psoriatic lesions,and might be associated with epidermal hyperproliferation.Hence,leptin may serve as a molecular linker between psoriasis and obesity.