摘要色素上皮衍生因子具有神经保护、抑制血管新生、抗肿瘤、抗炎、抗氧化等多种功能,成为肿瘤及血管新生、炎症性相关疾病治疗的新靶点.银屑病是慢性炎症性疾病并伴有异常血管新生,色素上皮衍生因子作为有效的血管生长抑制因子,在银屑病的研究中也逐渐受到关注.然而,色素上皮衍生因子在银屑病发病机制中的作用尚未明确.进一步探讨色素上皮衍生因子在银屑病发病机制中的作用,有望为银屑病治疗提供新途径.

abstractsPigment epithelium-derived factor (PEDF) has many activities,such as neuroprotective,anti-angiogenesis,anti-tumor,anti-inflammation,and antioxidant activities.It has become a novel target for the treatment of tumors,angiogenesis-and inflammation-related diseases.Since psoriasis is a chronic inflammatory skin disease associated with inappropriate angiogenesis,PEDF,as the most potent natural inhibitor of angiogenesis,has attracted more and more attention in the study of psoriasis.However,the role of PEDF in the pathogenesis of psoriasis is still unclear.To further clarify the role of PEDF in the pathogenesis of psoriasis may provide a novel treatment option for psoriasis.