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大环内酯类抗生素除抗菌作用外,还兼有抗炎和免疫调节作用,主要通过抑制中性粒细胞趋化、迁移,促进免疫细胞凋亡,减少炎症介质释放,下调黏附分子表达及影响细胞信号转导通路等交织作用共同发挥抗炎和免疫调节活性.在皮肤科应用方面,除用于感染性皮肤病外,对某些炎症性或免疫性皮肤病,如银屑病、玫瑰糠疹、痤疮、酒渣鼻、苔藓样糠疹、融合性网状乳头瘤病、色素性痒疹、家族性慢性良性天疱疮、大疱性类天疱疮等亦有较好的疗效.

Apart from antimicrobial effects,macrolide antibiotics also have anti-inflammatory and immunomodulatory effects via inhibiting the chemotaxis and migration of neutrophils,accelerating the apoptosis of immune cells,attenuating the secretion of inflammatory mediators,down-regulating the expression of adhesion molecules and affecting cellular signal transduction pathways.In dermatology,macrolide antibiotics not only are used to treat infectious dermatoses,but also show favorable therapeutic effects on some inflammatory or immune dermatoses such as psoriasis,pityriasis rosea,acne,rosacea,pityriasis lichenoides,confluent and reticulated papillomatosis,prurigo pigmentosa,Hailey-Hailey disease,bullous pemphigoid,etc.