摘要白细胞介素17C是不同于其他白细胞介素17家族的新型细胞因子,是一种来源于上皮细胞的多功能细胞因子,在多种病原感染和炎症反应中检测出优先诱导性的表达,主要通过与其高亲和性受体特异性结合,经自分泌方式作用于靶细胞或与其他细胞因子相互作用诱导相关抗菌肽、促炎症性细胞因子和趋化因子等的表达,参与了包括银屑病在内的多种上皮源性疾病的发生,可能在疾病的发病机制中起重要作用.

abstractsInterleukin (IL)-17C,a multifunctional cytokine derived from epithelial cells,is different from the other IL-17 family members.There is a preferential and inductive expression of IL-17C in multiple infections and inflammatory reactions.By specifically binding to its high-affinity receptor,IL-17C can act on target cells or interact on other cytokines in an autocrine manner,induce the expressions of antimicrobial peptides,pro-inflammatory cytokines and chemokines.It is involved in the initiation of multiple diseases of epithelial origin (including psoriasis),and may play an important role in their pathogenesis.The authors review the biological function of IL-17C and its relationship with psoriasis.