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白癜风是一种获得性色素脱失性皮肤疾病,其发病机制复杂.近年来研究表明,白癜风是一种多基因遗传病,尤其是泛发性白癜风与遗传密切相关.在近年研究中,认为谷胱甘肽巯基转移酶基因、过氧化氢酶基因、Toll样受体家族基因、酪氨酸酶基因、盘状结构域受体基因、人类白细胞抗原等位基因和超氧化物歧化酶基因等是白癜风易感基因.探讨白癜风的易感基因为进一步阐明其发病机制提供依据,对白癜风尤其是泛发性白癜风的早期诊断、治疗、预防具有重要作用.

Vitiligo is an acquired dermatosis characterized principally by skin depigmentation with complex pathogenesis.Recent studies have indicated that vitiligo is a polygenic disease,and generalized vitiligo is particularly closely related to heredity.Many predisposing genes have been discovered for vitiligo,including the glutathione S-transferase gene,Catalase gene,Toll-like receptor gene family,tyrosinase gene,discoidin domain receptor 1 gene,human leukocyte antigen alleles,superoxide dismutase gene,etc.To study the susceptible genes for vitiligo may provide a basis for the elucidation of vitiligo pathogenesis,and greatly benefit the early diagnosis,treatment and prevention of vitiligo,especially generalized vitiligo.