检索历史 清除

梅毒是由梅毒螺旋体引起的一种系统性的性传播疾病.感染梅毒后,机体对梅毒的免疫学反应复杂,多种细胞因子在梅毒的发病及病情进展中起重要作用.在梅毒早期,Th1型细胞因子介导的细胞免疫反应占优势,以利于机体清除梅毒螺旋体;随着病情进展,Th2型细胞因子介导的体液免疫反应逐渐增强,导致梅毒螺旋体的免疫逃逸.概述Th1型、Th2型、Th17型等7种细胞因子及一些趋化因子在梅毒发病过程中的作用.

Syphilis is a systemic sexually transmitted disease caused by Treponema pallidum (TP).TP infection may induce a complex immune response in the host,and a variety of cytokines play important roles in the occurrence and development of syphilis.In the early stage of the infection,Th1-type cellular immune responses,which are responsible for the clearance of TP,predominate.With disease progression,Th2-type humoral immune responses,which can result in the escape of TP from immunity,are gradually enhanced.This article describes the roles of 7 kinds of cytokines (including Thl-type,Th2-type,and Thl7-type cytokines) and some chemotactic factors in the pathogenesis of syphilis.