摘要成人Still病是一种炎症性自身免疫性疾病,其特征是高热、一过性皮疹、关节炎、肝脾肿大、多系统累及和实验室异常,包括中性粒细胞增多和高铁蛋白血症.研究表明,成人Still病患者促炎症细胞因子IL-1β、IL-6、IL-18均有升高,这些细胞因子诱导与维持Th17功能相关联.成人Still病的治疗主要包括非甾体抗炎药、糖皮质激素和抗风湿药物.生物制剂也常用于治疗成人Still病,不仅在治疗方面有应用前景,尚可部分解释该病的发病机制.

abstractsAdult-onset Still's disease (AOSD) is an inflammatory autoimmune disorder characterized by high fever,evanescent rash,arthritis,hepatosplenomegaly,multisystemic involvement and laboratory abnormalities including neutrophilic leukocytosis and hyperferritinaemia.It has been shown that some proinflammatory cytokines such as interleukin (IL)-1β,IL-6,and IL-18 are highly expressed in patients with AOSD.These cytokines are associated with the induction and maintenance of function of T helper type 17 (Th17) cells.The treatment of AOSD includes nonsteroidal anti-inflammatory drugs,glucocorticoids and antirheumatic drugs.Further more,biological agents are also usually used to treat AOSD,which not only have a promising prospect in clinical application,but also can partly explain the pathogenesis of this disease.