摘要银屑病是一种病因不明的慢性炎症性、免疫性疾病,其皮损中可发现明显增多的树突细胞和效应性T细胞浸润,提示树突细胞参与了银屑病的炎症反应.正常皮肤组织中,主要分布3类树突细胞:表皮朗格汉斯细胞、真皮髓系树突细胞和浆细胞样树突细胞.在银屑病皮损组织中,3类树突细胞与T细胞、角质形成细胞、中性粒细胞的相互作用可引发和加重皮肤中的炎症反应.此外,浆细胞样树突细胞在以Toll样受体依赖方式分泌的Ⅰ型干扰素还可能促进髓系树突细胞的活化及炎症介质的释放.

abstractsPsoriasis is a chronic inflammatory and immunologic disease of unknown etiology.It has been found that increased number of dendritic cells (DCs) and effector T-lymphocytes infiltrate skin lesions of psoriasis,indicating that DCs are involved in the inflammatory response in psoriasis.In normal skin,there are mainly three kinds of DCs:epidermal Langerhans cells,dermal myeloid DCs and plasmacytoid DCs.In skin lesions of psoriasis,the three kinds of DCs interact with T cells,keratinocytes and neutrophilic granulocytes,which can induce and aggravate inflammatory responses.In addition,type Ⅰ interferon secreted by plasmacytoid DCs in a Toll-like receptor-dependent manner can enhance the activation of myeloid DCs and release of inflammatory mediators.