摘要载脂蛋白B mRNA编辑酶催化多肽家族是一种通过脱氨酶作用编辑DNA和RNA序列的抗病毒活性蛋白分子.最初载脂蛋白B mRNA编辑酶催化多肽3家族因具有抑制HIV复制的作用而得到关注.随着研究的深入,发现载脂蛋白B mRNA编辑酶催化多肽家族在与人类疾病密切相关的其他病毒感染如人类嗜T细胞病毒、丙型肝炎病毒、乙型肝炎病毒、人乳头瘤病毒、单纯疱疹病毒中同样发挥重要作用.此外,载脂蛋白B mRNA编辑酶催化多肽的编辑作用不仅是病毒基因多样性和进化性的来源,也是肿瘤发生的重要原因.

abstractsThe apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family are a group of active antiviral proteins that can edit DNA and RNA sequences by deamidizing enzymes.The APOBEC-like 3 (APOBEC3) family was firstly noticed for its inhibitory effect against human immunodeficiency virus type 1 (HIV-1) infection.With the development of research,the APOBEC family have been found to play an important role in other viral infections closely related to human diseases,such as human T-cell lymphotropic virus (HTLV),hepatitis C virus (HCV),hepatitis B virus (HBV),human papilloma virus (HPV),herpes simplex virus (HSV),etc.In addition,the editing function of the APOBEC family contributes not only to viral genetic diversity and evolution,but also to tumorigenesis.