摘要半胱氨酸天冬氨酸蛋白酶8与死亡受体介导的凋亡密切相关.近年来,对半胱氨酸天冬氨酸蛋白酶8参与凋亡机制的研究取得了一些进展,发现半胱氨酸天冬氨酸蛋白酶8除凋亡以外的其他生物学功能,如参与T细胞增殖和免疫应答、细胞黏附/迁移、血管内皮形成等.作为Fas凋亡途径关键的启动者,半胱氨酸天冬氨酸蛋白酶8与皮肤损伤修复、瘢痕形成、扁平苔藓等密切相关,并在抗炎中发挥一定作用.

abstractsCaspase 8 is closely associated with death receptor-mediated apoptosis.In recent years,some progress has been made in studies on the roles of caspase 8 in apoptosis.Besides initiating apoptosis,caspase 8 has many other biological functions,such as participating in T cell proliferation and immune responses,cell adhesion/migration,vascular endothelium formation,etc.As a key initiator of the Fas-mediated apoptotic pathway,caspase 8 is closely associated with repair of skin damage,cicatrization and lichen planus,and also plays some roles in counteracting inflammation.