摘要单纯糠疹是一种发生于儿童的局限性色素减退性疾病,有轻微鳞屑,边界不清.其发病机制尚不清楚,特应性体质、干燥及日光照射是潜在的危险因素.组织病理显示,病变区域表皮基底层黑素含量较皮损周围正常皮肤处明显减少,免疫组化显示,病变区表皮基底层黑素细胞含量与皮损周围正常皮肤差异无统计学意义.治疗中可以使用润肤剂.新近研究显示,钙调磷酸酶抑制剂等抗炎药物可以起到良好的治疗及预防复发的疗效.

abstractsPityriasis alba,a skin disorder mostly occurring in children,is characterized by localized hypopigmented,slightly scaling patches with indistinct margins.The etiology of pityriasis alba is not well established.Atopy,xerosis,and sun exposure are potential risk factors for it.Histopathologically,there is a marked reduction in epidermal melanin content in lesional skin compared with perilesional normal skin,but immunohistochemical studies show no significant difference in the number of melanocytes between lesional and perilesional skin.It may be treated with lubricants and emollients.Recent studies have shown that antiinflammatory drugs,such as calcineurin inhibitors,exhibit favorable efficacy in treating and preventing the recurrence of pityriasis alba.