摘要组胺是免疫反应中的重要介质,组胺H4受体是近年来新发现的组胺受体,主要表达于免疫器官及细胞上.研究表明,组胺H4受体参与特应性皮炎发病过程中的免疫炎症调节、瘙痒反应及表皮增殖.组胺H4受体的特应性拮抗剂也能影响特应性皮炎的病程发展,通过T细胞、抗原提呈细胞、角质形成细胞等发挥抗炎、调节免疫及其抗瘙痒作用,减轻了特应性皮炎的湿疹样皮炎、顽固性瘙痒的临床症状,有望成为一种新型治疗特应性皮炎的有效手段.

abstractsHistamine is an important mediator in inflammatory responses,and histamine H4 receptor is a newly discovered histamine receptor mainly expressed on immune organs and cells.Recent researches have indicated that histamine H4 receptor participates in immunoregulation,pruritus and epidermal proliferation in the pathogenesis of atopic dermatitis.Specific antagonists of histamine H4 receptor can affect the development and attenuate clinical symptoms of atopic dermatitis,such as eczematoid dermatitis and intractable itch,byexerting anti-inflammatory,immunoregulatory and anti-pruritic effects via T-lymphocytes,antigen-presenting cells and keratinocytes.Hence,histamine H4 receptor antagonists are expected to be a novel and effective approach to the treatment of atopic dermatitis.