摘要Foxp3调节性T细胞是具有免疫抑制功能的CD4+T淋巴细胞的一个亚群,在自身免疫性疾病、器官移植免疫耐受、抗肿瘤免疫及过敏性疾病中均发挥重要作用.近年研究发现,调节性T细胞在一些病原体感染过程中扩增并聚集到感染部位,通过细胞直接接触或分泌抑制性细胞因子如,白细胞介素10、转化生长因子β等,限制效应细胞免疫应答,从而减轻机体免疫反应过程对宿主的病理性损伤,同时也可减弱机体清除病原微生物的能力,导致感染持续存在.

abstractsFoxp3+ regulatory T cells (Tregs),an immunosuppressive CD4+ T lymphocyte subset,play important roles in autoimmune diseases,immune tolerance to organ transplants,antitumor immunity and allergic diseases.Recent studies have demonstrated that Tregs can proliferate and gather at sites of infection with some pathogens,limit immune responses through direct intercellular contact or secretion of suppressive cytokines (such as interleukin-10 and transforming growth factor β),then attenuate pathological damages to the host induced by immune responses,weaken the capacity to clear pathogenic microorganisms,and result in the persistence of infection.