换一批
换一批摘要兜甲蛋白是角质包膜的主要组成成分,对表皮的屏障功能起重要作用.该基因的表达调控受多个转录因子之间复杂的相互作用共同调控.兜甲蛋白基因突变可导致兜甲蛋白角皮症,突变体兜甲蛋白发生核易位干扰了角质形成细胞的终末分化,从而引起相应临床表型.兜甲蛋白在特应性皮炎和银屑病皮损内亦出现表达减少,其表达异常受相关细胞因子的影响.
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abstractsLoricrin,as the major component of the cornified envelope,plays an important role in epidermal barrier function.The expression of loricrin gene is co-regulated by complex interactions between multiple transcription factors.Loricrin gene mutations can lead to loricrin keratoderma.Nuclear translocation of mutant loricrin can interfere with terminal differentiation of keratinocytes,and cause corresponding clinical phenotypes.In addition,the expression of loricrin is decreased in lesions of atopic dermatitis and psoriasis,which may be attributed to some cytokines.
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关键词
皮肤疾病基因表达调控突变银屑病兜甲蛋白皮肤屏障Skin diseasesGene expression regulationMutationPsoriasisLoricrinSkin barrier
栏目名称
DOI
10.3760/cma.j.issn.1673-4173.2015.05.015
发布时间
2015-10-10
基金项目
国家自然科学基金（81071286）
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