摘要表观遗传学主要是研究在不改变DNA序列的情况下,发生的基因表达水平可遗传的变化,主要包括DNA甲基化、组蛋白修饰和非编码RNA调控.皮肤T细胞淋巴瘤是一组原发于皮肤的T淋巴细胞恶性增殖性疾病,蕈样肉芽肿和Sezary综合征是最常见的皮肤T细胞淋巴瘤.近年来研究表明,表观遗传学不仅在皮肤T细胞淋巴瘤的发生发展中起重要作用,而且可以通过改变表观遗传达到治疗皮肤T细胞淋巴瘤目的.

abstractsEpigenetics means heritable changes in gene expressions without alterations in DNA sequence, and mainly involves DNA methylation, histone modification and non-coding RNA regulation.Cutaneous T-cell lymphoma is a class of malignant T-cell lymphoproliferative diseases originated from the skin.Mycosis fungoides and Sezary syndrome are the most common cutaneous T-cell lymphoma.Recent studies have shown that epigenetics not only plays an important role in the occurrence and development of cutaneous T-cell lymphoma, but also provides insights into the treatment of cutaneous T-cell lymphoma.