摘要脂联素是一种主要由脂肪细胞分泌的内源性生物活性蛋白质,以三聚体、六聚体和高分子量多聚体3种不同的形式存在于外周血中.脂联素与其受体结合后,通过激活下游的信号通路,发挥调控新陈代谢、调节免疫平衡、抑制细胞增殖和炎症反应、维持血管稳态等重要作用,而其免疫调节作用日益成为研究的焦点.近年来研究表明,脂联素积极参与免疫性皮肤病的进程,随着对脂联素免疫调节作用研究的不断深入,其与免疫性皮肤病的关系亦取得了较大进展.拟为今后免疫性皮肤病的临床治疗及用药提供新的方法和思路.概述脂联素与银屑病、系统性红斑狼疮、硬皮病及干燥综合征等免疫性皮肤病的关系.

abstractsAdiponectin is an endogenous bioactive protein secreted mainly by adipocytes, and exists in peripheral blood in three forms, including trimers, hexamers and high-molecular weight multimers.By binding to its receptor and activating downstream signaling pathways, it plays an important role in regulating metabolism and immune balance, inhibiting cell proliferation and inflammatory reaction, and maintaining vascular homeostasis.The immunoregulatory effect of adiponectin has been gradually becoming a focus of researches.Recent studies have indicated that adiponectin is actively involved in the development of immune-mediated skin diseases.With further insights into the immunoregulatory effect of adiponectin, great progress has been made in elucidating the relationship between adiponectin and immune-mediated skin diseases, which will provide new methods and ideas for clinical treatment of immune-mediated skin diseases.This review summarizes the relationship between adiponectin and immune-mediated skin diseases, such as psoriasis, systemic lupus erythematosus, scleroderma and Sj(o)gren's syndrome.