摘要痤疮丙酸杆菌在痤疮发病机制中的作用受到越来越多的关注.研究发现,痤疮丙酸杆菌在痤疮患者及健康志愿者皮肤中分布具有菌株差异性,其中痤疮患者主要是Ⅰ型,而健康志愿者主要是Ⅱ、Ⅲ型,痤疮丙酸杆菌的这种菌株差异性在其发病机制中有所体现.不同类型痤疮丙酸杆菌基因具有差异性.其中Ⅰ型缺乏完整的具有防御作用的CRISPR系统,具有某些致病基因特性,其致病能力较Ⅱ型强,Ⅰ、Ⅱ型之间可能存在竞争关系,最终优势菌群的不同在痤疮是否发病中可能占有重要作用,为进一步研究痤疮丙酸杆菌的发病机制及痤疮的诊治带来了新的视角.

abstractsThe role of Propionibacterium acnes in the pathogenesis of acne has attracted more and more attention.Recent studies have demonstrated that there is a significant difference in the type of Propionibacterium acnes distributed in the skin between acne patients and healthy volunteers.Propionibacterium acnes type Ⅰ exists most frequently in patients with acne, while types Ⅱ and Ⅲ exist in healthy volunteers.This difference in Propionibacterium acnes strains is also reflected in the pathogenesis of acne.In addition, the genome sequences are different between different types of Propionibacterium acnes.Due to the lack of the intact defense system CRISPR, Propionibacterium acnes type Ⅰ show characteristics of some pathogenic genes, and have a stronger pathogenecity than the type Ⅱ strains.Moreover, there may be competitions between Propionibacterium acnes types Ⅰ and Ⅱ, and the dominant type may determine whether acne occurs.These findings may offer new ideas for further studies on the role of Propionibacterium acnes in the pathogenesis of acne and for acne treatment.