摘要梅毒不同的临床表现多取决于细胞免疫的强度和持续时间,巨噬细胞、CD4+T淋巴细胞、CD8+T淋巴细胞、自然杀伤细胞均在梅毒感染的细胞免疫中起重要作用.而与HIV合并感染更是增加了其免疫机制的复杂性和临床表现的多形性.在与HIV合并感染的二期梅毒中,Th1、Th17型细胞免疫增强,而Th2型细胞免疫的改变目前尚不确切.梅毒与HIV合并感染时两者的免疫机制、病程以及疗效均可能发生影响,因此,有必要进行梅毒患者的HIV筛查和HIV感染者的梅毒筛查,以便获得及时有效的治疗.

abstractsThe intensity and duration of cellular immune response determine differences in clinical manifestations of syphilis.Macrophages,CD4+ T lymphocytes,CD8+ T lymphocytes and natural killer (NK) cells all play important roles in cellular immunity in syphilis.Concurrent human immunodeficiency virus (HIV) infection increases the complexity of immune pathogenesis as well as variety in clinical manifestations of syphilis.In secondary syphilis concurrent with HIV infection,T helper type 1 (Th1) and Th17 cell-mediated immunity are enhanced,while changes in Th2 cell-mediated immunity remain unclear.The concurrence of syphilis and HIV infection may alter their immunologic mechanisms,clinical course and therapeutic outcomes.Thus,it is necessary for timely and effective treatment to screen for HIV infection in patients with syphilis and for syphilis in patients with HIV infection.