摘要目的 探讨银屑病患者皮肤CD69+T细胞的表达及其与疾病活动性的关系.方法 免疫组化检测31例银屑病患者皮损和非皮损中CD69+T细胞在皮肤中的表达,与6例健康人进行对照.结果 CD69+T细胞主要分布于皮肤真皮.31例银屑病患者皮损和非皮损的真皮中,CD69+T细胞分别为(35.16±12.67)％和(8.70±3.29)％,皮损明显高于非皮损(t=12.5,P＜0.01).6例健康人对照皮肤中CD69+T细胞(8.71±2.55)％,明显低于银屑病皮损(t=5.03,P＜ 0.01),与非皮损相比,差异无统计学意义(t=0.05,P＞ 0.05).20例急性期与1 1例稳定期银屑病患者皮损中CD69+T细胞分别为(40.89±10.31)％和(24.46±9.49)％,急性期明显高于稳定期(t=0.36,P＜ 0.01).结论 银屑病患者皮损中CD69+T细胞表达增高,与疾病的活动性有关.

abstractsObjective To measure the expression of CD69+ T lymphocytes in skin lesions of patients with psoriasis,and to explore its relationship with disease activity.Methods Lesional and non-lesional skin samples were collected from 31 patients with psoriasis,and normal skin samples obtained from 6 healthy individuals served as controls.Immunohistochemical staining was performed to measure the expression of CD69+ T lymphocytes in these skin samples.Results CD69+ T lymphocytes were mainly distributed in the dermis.The percentage of CD69+ T lymphocytes was significantly higher in lesional skin than in non-lesional skin (35.16％ ± 12.67％ vs.8.70％ ± 3.29％,t =12.5,P ＜ 0.01),higher in lesional skin from 20 patients with acute psoriasis than in that from 11 patients with stable psoriasis (40.89％ ± 10.31％ vs.24.46％ ± 9.49％,t =0.36,P ＜ 0.01),but significantly lower in normal control skin than in lesional skin (8.71％ ± 2.55％ vs.35.16％ ± 12.67％,t =5.03,P ＜ 0.01),and insignificantly different between normal control skin and nonlesional skin (t =0.05,P ＞ 0.05).Conclusion The expression of CD69+ T lymphocytes is markedly increased in psoriatic lesions,which may be associated with disease activity.