摘要光线性角化病是一种发生于曝光部位的表浅性皮肤病,其发病与长期紫外线照射所造成的基因突变,氧化应激,炎症反应,免疫抑制,细胞凋亡受损,细胞生长、增殖及组织重塑功能失调相关.光线性角化病目前治疗主要是针对皮损治疗和区域性治疗,针对皮损治疗包括冷冻、切除术、激光术,区域性治疗包括外用氟尿嘧啶、咪喹莫特、双氯芬酸、巨大戟醇甲基丁烯酸酯、维A酸及光动力治疗.

abstractsActinic keratosis (AK) is a kind of superficial skin disease occurring at sun-exposed sites.The occurrence of AK is associated with long-term ultraviolet radiation-induced gene mutations,oxidative stress,inflammation,immunosuppression,impaired apoptosis,dysregulation of cell growth,proliferation and tissue remodeling.Currently,the treatment of AK mainly includes lesion-directed and field-directed therapies.Lesion-directed therapies include cryotherapy,ectomy and lasers,and field-directed therapies include externally applied agents such as fluorouracil,imiquimod,diclofenac,ingenol mebutate,tretinoin,and photodynamic therapy.