摘要白细胞介素36主要分布在皮肤、支气管上皮和脑组织中,通过与受体复合体(白细胞介素36受体和白细胞介素1受体辅助蛋白)结合作用于上皮细胞、免疫细胞等,在固有免疫和适应性免疫中发挥重要作用.白细胞介素36通过诱导促炎症细胞因子、抗菌肽、趋化因子等促进炎症反应以抵御外界病原微生物.同时由于促炎症细胞因子及趋化因子等释放,诱发银屑病等自身免疫性疾病或免疫相关的炎症性疾病.白细胞介素36受体广泛低表达,且未被高度调控,在皮肤中能与分布广泛的白细胞介素36发挥其免疫学效应,因此,抗白细胞介素36受体的抗体可成为银屑病的潜在治疗.

abstractsInterleukin-36 (IL-36) is mainly expressed in the skin,bronchial epithelium and brain tissues,and plays an important role in innate immunity and adaptive immunity by acting on epithelial cells and immune cells via binding to a heterodimer receptor comprised of IL-36 receptor (IL-36R) and IL-1 receptor accessory protein.IL-36 can induce the expressions of pro-inflammatory cytokines,antimicrobial peptides and chemokines to defend against pathogens in the environment.The release of pro-inflammatory cytokines and chemokines can also cause the occurrence of autoimmune diseases or immune-related inflammatory diseases,such as psoriasis.IL-36R,which is widely expressed at low levels and does not seem to be highly regulated,exerts immunological effects via binding to widely distributed IL-36.Therefore,anti-IL-36R antibodies are expected to be a potential therapy for psoriasis.