摘要白癜风是一种皮肤色素脱失性疾病,以表皮功能性黑素细胞破坏为主要特征.目前研究支持其发病与遗传、免疫、氧化应激、神经-体液等机制有关.其中,T淋巴细胞介导的免疫反应在白癜风发病中起重要作用.CD4+T细胞亚群Th1、Th2、Th17、调节性T细胞通过分泌多种细胞因子调节其他免疫细胞的功能、诱导黑素细胞凋亡.CD8+T细胞可经由细胞毒作用直接杀伤黑素细胞.另一方面,自身耐受功能障碍、自身反应性T细胞数量和活性的增加可以增强T细胞对黑素细胞的免疫反应.除此以外,恒定型自然杀伤T细胞、记忆性T细胞等对白癜风免疫相关发病有一定的作用.

abstractsVitiligo is a depigmented skin disease,characterized by the destruction of functional melanocytes in the epidermis.Present studies have proved that the occurrence of vitiligo is associated with genetics,immunity,oxidative stress,neural and humoral mechanisms and so on.Among these mechanisms,T cell-mediated immune responses play an important role in the occurrence of vitiligo.The CD4 + T cell subsets,including T-helper 1 (Th1) cells,Th2 cells,Th17 cells and regulatory T (Treg) cells,can regulate the function of other immune cells and induce apoptosis of melanocytes by secreting various cytokines.CD 8+ T cells can directly kill melanocytes by exerting cytotoxic effects.On the other side,the breakdown of autotolerance,increased number and activity of autoreactive T cells can enhance the T cell immune response against melanocytes.Besides these mechanisms,invariant natural killer T cells and memory T cells both play a certain role in the immunological pathogenesis of vitiligo.