摘要IntroductionGiant condyloma acuminatum, which is also known as Buschke-Loewenstein tumor (BLT), is a uncommon sexually-transmitted disease affecting the genitals and characterized by a slow and locally-invasive growth pattern. It was first reported in 1925[1], and was defined as"carcinoma-like condylomata acuminate of the penis"by Loewenstein in 1938[2]. The typical clinical manifestations included exophytic, fungating masses, sometimes with a cauliflower-like morpho-logy. Therapies including surgical excision are effec-tive to the lesions of giant condyloma acuminatum, but the high recurrence rate brings troubles and pain to patients. In this report, we used electrosurgery and carbon dioxide (CO2) laser as the primary treatment followed by 5-aminolevulinic acid-photodynamic therapy (5-ALA PDT), and achieved 100％ clinical efficacy on a case of giant condyloma acuminatum.