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Skin Microbiota and the Skin Barrier

Skin Microbiota and the Skin Barrier

摘要The skin constitutes the primary barrier between the human body and the external environment. The skin microbiome plays an important role in the microecosystem on the skin surface and mediates multiple facets of the skin barrier function, including physical, chemical, microbial, and immune barriers. In this review, we discuss the host–microbiota interactions in barrier maintenance and disruption, implications for skin disorders such as atopic dermatitis, psoriasis, and rosacea, and the latest strategies for targeting the skin microbiota to improve the skin barrier.

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abstractsThe skin constitutes the primary barrier between the human body and the external environment. The skin microbiome plays an important role in the microecosystem on the skin surface and mediates multiple facets of the skin barrier function, including physical, chemical, microbial, and immune barriers. In this review, we discuss the host–microbiota interactions in barrier maintenance and disruption, implications for skin disorders such as atopic dermatitis, psoriasis, and rosacea, and the latest strategies for targeting the skin microbiota to improve the skin barrier.

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作者 Wu Ming-Yang [1] Yao Xu [1] 学术成果认领
作者单位 Department of Allergy and Rheumatology, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, Jiangsu 210042, China [1]
栏目名称 Review Article
DOI 10.1097/JD9.0000000000000334
发布时间 2025-03-04
基金项目
This work was supported by the Nanjing Incubation Program for National Clinical Research Center Key Project of Social Development in Jiangsu Province National Natural Science Foundation of China CAMS Innovation Fund for Medical Sciences (CIFMS) National Key R&D Program of China
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