摘要阴茎是男性外生殖器的重要构成部分.先天疾病或外伤可能会导致阴茎发育畸形或缺损,最终需要重建.随着组织工程学的发展,阴茎海绵体组织工程学研究也日益成为阴茎重建的核心内容.目前阴茎海绵体组织工程学研究主要集中在支架制备以及移植细胞(包括血管内皮细胞和平滑肌细胞)的研究.近几年,随着干细胞技术、基因技术以及神经再造技术等的联合发展,将组织工程阴茎海绵体的发展又推上了另一个高度.组织工程的研究为修复阴茎海绵体结构及重建其正常功能提供了可能.拟对近年组织工程在阴茎海绵体重建方面的相关研究进展作一综述.

abstractsPenis is one of the most important components of male external genitalia.Congenital abnormalities and trauma may lead to genitourinary organ damage or default,which require reconstruction.With the development of tissue engineering(TE),penile corpora cavernosa tissue engineening has becoming the core of the penis reconstruction.Recent researches mainly focus on forming scaffolds and transplanting cells(including of endothelial cells and caveruosal smooth muscle cells). Recently, stem cell technology, gene therapy and nervous reconstructive techniques have been combined to promote the development of tissue engineering.Tissue engineering has been thought to be able to make possible the restoring and constructing of the structure and normal funetion of penile corpora cavernosa.This paper gives a review of the recent progress in associated researches on tissue engineering of the penile corpora cavernosa.