摘要急性心肌梗死后由于大量心肌细胞坏死、纤维瘢痕形成等原因造成心室重构和心功能下降,严重影响心梗患者的远期预后.天然材料或人工合成的水凝胶是一种新兴的生物替代材料,具有良好的亲水性和组织相容性,可模拟心肌细胞微环境的生化和机械特性,目前已广泛地应用于心肌梗死的治疗研究中.水凝胶可单独应用,也可作为细胞/药物运载工具和平台.研究表明:将水凝胶-干细胞-药物复合物进行心肌注射后,可以增加室壁厚度,促进新生血管形成,提高移植干细胞的存活率,并实现生物活性药物的控释,在一定程度上抑制梗死后心室重构,促进心功能的恢复.就目前可注射水凝胶在治疗心肌梗死方面的相关研究进展作一综述.

abstractsDue to myocardial necrosis and fibrous scar formation after acute myocardial infarction,patient's ventricular remodeling and cardiac function is reduced,which will cause serious impact on the long-term prognosis of patients with myocardial infarction.As new biological substitute materials,the hydrogels are superior in hydrophilicity and biocompatibility and have been widely used in the research of myocardial infarction's treatment.The hydrogels can be used alone or served as a promising cell/drug delivery vehicle.Many reports show that intramyocardial injection of hydrogels attached with stem cells and drugs can prevent left ventricle (LV) wall thinning,increase arteriole and capillary density,raise restoration ratio of implanted stem cells,facilitate controlled release of bioactive drugs,limit post-ischemic remodeling and preserve LV function in a certain extent.This article reviews injectable hydrogels" research progress in the treatment of myocardial infarction.