摘要目的:探究溶质载体家族24成员5（SLC24A5）的表达与皮肤黑色素瘤（SKCM）细胞增殖和侵袭的关系，对SLC24A5作为SKCM的潜在生物标志物和治疗靶点的可能性进行初步探讨。方法:利用生物信息学的方法搜集相关信息，随后建立敲低SLC24A5的MEL-526和SK-HEL-5黑色素瘤细胞模型，通过Western blot与实时定量聚合酶链式反应（qPCR）实验验证SLC24A5的敲低效率，并探讨敲低SLC24A5对SKCM细胞增殖和侵袭的影响。结果:SLC24A5在SKCM组织中的表达显著高于癌旁正常组织，高表达SLC24A5的患者的预后更差。敲低SLC24A5后，MEL-526和SK-HEL-5细胞的增殖受到抑制。结论:SLC24A5在SKCM的进展中扮演着重要角色，有成为SKCM的治疗靶点和生物标志物的潜力。

abstractsObjective:To explore the relationship between the expression of solute carrier family 24 member 5(SLC24A5) and skin melanoma (SKCM) cell proliferation and invasion, and to explore the possibility of SLC24A5 as a potential biomarker and therapeutic target of SKCM.Methods:The bioinformatics method was used to collect relevant information, and then the MEL-526 and SK-HEL-5 melanoma cell models of knockdown SLC24A5 were established. The knockdown efficiency wasverified by Western blot and real-time quantitative polymerase chain reaction (qPCR) experiments, and the cell proliferation and invasion of the SKCM cells after knockdown of SLC24A5 were detected.Results:The expression of SLC24A5 in SKCM tissue was significantly higher than that in normal tissues adjacent to cancer. Patients who highly expressed SLC24A5 had a worse prognosis. After knocking down SLC24A5, the proliferation of MEL-526 and SK-HEL-5 cells was inhibited.Conclusions:SLC24A5 plays an important role in the progress of SKCM and has the potential to become a therapeutic target and biomarker of SKCM.