摘要目的 探讨抗幽门螺杆菌(helicobacter pylori,HP)感染在治疗特发性血小板减少性紫癜(idiopathic thrombocytopenia purpura,ITP)中的作用.方法 收集2008年5月至2010年5月在本院住院的ITP合并HP感染患者(PLT＜20×109/L)38例和门诊患者[PLT:(20～50)×109/L]20例作为研究对象.将住院的38例患者随机分为治疗组(n=19)和对照组(n=19).治疗组(n=19)在应用糖皮质激素治疗ITP同时加用抗HP治疗；对照组(n=19)单纯应用糖皮质激素治疗ITP.20例门诊患者也随机分为两组,治疗组(n=10)予抗HP治疗,对照组(n=10)仅进行临床观察.分别于治疗10 d后和6个月后复查患者血小板计数.(本研究遵循的程序符合本院人体试验委员会所制定的伦理学标准,得到该伦理会批准,分组征得受试对象本人的知情同意,并与之签订临床研究知情同意书).结果 住院患者10 d后治疗组和对照组血小板均数差异,无统计学意义(P＞0.05),随诊至6个月后出现统计学差异(P＜0.05)；门诊治疗组血小板数值恢复较观察组明显(P＜0.05).结论 根除HP是治疗ITP合并HP感染患者的一个有效途径.

abstractsObjective To investigate the result of anti-helicobacter pylori(HP)in the treatment of idiopathic thrombocytopenic purpura(ITP).Method From May 2008 to May 2010,50 patients who were diagnosed as ITP with HP infection were included into this study.38 hospitalized patients(PLT＜20 ×109/L)were divided into research group(n=19)and control group(n=19),randomly.The research group was treated with glucocorticoid and anti-HP,but the control group was treated with glucocorticoid only.20 cases of outpatients[PLT:(20～50)× 109/L]were divided into research group(n=10)and control group (n=10),randomly too.The research group was treated with the anti-HP infection,and the control group was just observed.The PLT of patients in each group were detected after 10 days and 6 months of therapy.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Cangzhou Center Hospital.Results There was no significant difference between research and control group after 10 days of therapy(P＞0.05),but there was significant difference after 6 months(P＜0.05); the PLT was significantly higher in outpatient treatment group than in the observation group(P＜0.05).Conclusion Completely treatment of HP was an effective way to curing ITP with HP infection.