摘要成体肝脏具有极强的再生能力,当肝脏受到严重的损伤或成熟肝细胞增生受到抑制时,肝内干细胞将被活化.成体肝脏干细胞具有维持自我更新的能力,对肝脏损伤或疾病产生反应并进行修复,与急性肝损伤、肝硬化、肝细胞性肝癌等疾病的发生与发展密切相关.
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abstractsThe liver has enormous regenerative capacity.Following acute liver injury,hepatocyte division regenerates the parenchyma;but if this capacity is overwhelmed during massive or chronic liver injury,the intrinsic hepatic stem cells are activated.Hepatic stem cells have the ability to maintain self-renew and respond to injury when challenged and closely related to intractable liver diseases,such as acute liver failure,cirrhosis and hepatocellular carcinoma.
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