换一批IDO的免疫调节机制及在移植耐受和肿瘤逃逸中的作用
Immune regulative mechanism of indoleamine 2,3-dioxygenase and its effects in transplantation tolerance and tumor escape
摘要吲哚胺2,3双加氧酶(IDO)是一种能分解色氨酸的细胞内血红素单体蛋白,实验证明通过色氨酸的剥夺和分解产物聚集可以抑制T细胞成熟并促其凋亡.随着对IDO免疫调节机制研究的不断累积,其在器官移植和肿瘤治疗等领域的临床应用前景令人期待.本文就IDO的免疫调节机制及在移植耐受和肿瘤逃逸中的作用做一综述.
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abstractsIndoleamine 2,3-dioxygenase(IDO)is an intracellular hemeprotein enzyme which catalyses the essential amino acid tryptophan.Accumulating evidences have demonstrated that tryptophan depletion and its toxic metabolites can suppress local allogeneic T cell proliferation and lead to apoptosis.With the study of the mechanism of immune regulation of IDO goes further,it have emerged as a proming enzyme in organ transplantation and tumor treatment.We reviewed in the article the immune regulative mechanism of IDO and its effects in transplantation tolerance and tumor escape.
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医学主题词
移植耐受(Transplantation Tolerance)肿瘤逃逸(Tumor Escape)免疫调节(Immunomodulation)氧(Oxygen)色氨酸(Tryptophan)
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DOI
10.3760/cma.j.issn.1673-4203.2009.10.020
发布时间
2009-12-04（万方平台首次上网日期，不代表论文的发表时间）
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