摘要原发性肝癌由于缺乏特异性和灵敏度均高的标志物,确诊时已多属中、晚期,又由于缺乏有效治疗,因而预后差.近年来,肝癌相关基因和蛋白标志物大量涌现,本文就AFP-L3、GP73及抑癌基因DLC-1(deleted in liver caneer-1)与肝癌发生发展的关系进行阐述,为肝癌的早期诊断和判定预后提供一些新的线索.

abstractsPrimary liver cancer is commonly diagnosed in intermediate and advanced stage because of the lack of the markers with preferable specificity and sensitivity.Meanwhile,the lack of effective treatment leads to poor prognosis.In recent years.a large number of liver cancer-related genes and protein markers have emerged.In this article we reviewed the relationship of AFP-L3,GP73 and tumor suppressor genes DLC-1 (deleted in live cancer-1)and the fcarcinogenesis and progress of primary liver cancer,and provided some new clues for the early diagnosis and the judgment of prognosis of liver cancer.