摘要青光眼病理性高眼压的常见原因是房水流出受阻，因此房水流出通道的形态观察和功能研究是青光眼防治的重点。研究房水流出通道的形态及功能对研究青光眼发病机制、选择手术方式和开发靶向药物均有重要意义。房水流出成像方式中眼前段相干光断层扫描及血管成像、超声生物显微镜活体显像，可对房水流出通道进行结构性评估；而静态和实时房水血管造影为功能性评估。目前尚缺乏房水结构流出特征与功能流量值之间的精确关系研究。使用房水血管造影术可研究与评价青光眼的药物疗效。房水血管造影术有助于引导小梁网靶向的微创青光眼手术以获得更好的降眼压效果。但房水血管造影术有创，目前只能在手术室使用。未来尚需进一步改进评估房水流出通道的方法，以期在临床上通过结构和功能评估相结合，更好地了解房水流出通道和眼前段结构，提高青光眼诊治水平。( 国际眼科纵览，2020, 45: 397-403)

abstractsThe common reason of pathological high intraocular pressure in glaucoma is the obstruction of aqueous humor outflow, so the morphological observation and functional study of aqueous humor outflow channel is the focus of glaucoma prevention and treatment. The study of the morphology and function of aqueous humor outflow channel is of great significance for the study of the pathogenesis of glaucoma, the selection of surgical methods and the development of targeted drugs. The imaging methods of aqueous humor outflow include anterior segment optical coherence tomography (AS-OCT), OCT angiography (OCTA), ultrasound biomicroscopy (UBM) in vivo imaging, static and real-time aqueous humor angiography, etc. OCT and UBM can evaluate the structure of aqueous humor outflow channel, while aqueous humor angiography is a functional assessment. At present, there is no precise relationship between the outflow characteristics of aqueous humor structure and the value of functional flow. Aqueous humor angiography can be used to study and evaluate the drug efficacy of glaucoma. It is also helpful to guide trabecular meshwork targeted minimally invasive glaucoma surgery to achieve a better effect of lowering intraocular pressure. However, aqueous humor angiography is invasive and can only be used in the operating room. In the future, the method of evaluating aqueous humor outflow pathway needs to be further improved in order to better understand the structure of aqueous humor outflow pathway and anterior segment structure and improve the level of diagnosis and treatment of glaucoma through the combination of structural and functional evaluation. ( Int Rev Ophthalmol, 2020, 45: 397-403)