摘要单纯疱疹病毒性基质坏死型角膜炎(herpes simplex virus necrotizing stromal keratitis，HSV NSK)是一种较为少见的、主要表现为角膜基质坏死的眼病，其可导致视力下降、角膜穿孔，甚至失明、眼球摘除等严重后果。目前针对HSV NSK的治疗方法分为非手术治疗和手术治疗。非手术治疗包括核苷类似物等抗病毒药物、靶向γ-干扰素的反义寡核苷酸药物、富马酸二甲酯、环孢素A、疫苗等。对于非手术疗法无法控制的严重病例，需进行手术治疗，常见的术式为穿透性角膜移植、深板层角膜移植、多层羊膜移植、结膜瓣覆盖等。 (国际眼科纵览，2022, 46：247-252)

abstractsHerpes simplex virus necrotizing stromal keratitis (HSV NSK) is a kind of rare eye disease mainly characterized by stromal necrosis, which can lead to vision loss, corneal perforation, even blindness and enucleation. At present, the management of HSV NSK can be divided into non-surgical procedure and surgical treatment. Non-surgical procedure includes antiviral drugs such as nucleoside analogues, IFN-γ-ASON, DMF, CsA, vaccine, etc. In the event of serious cases beyond the control of non-surgical therapy, surgical management is necessary. Common clinical surgeries include penetrating keratoplasty (PKP), deep anterior lamellar keratoplasty (DALK), multilayer amniotic membrane transplantation (AMT), and conjunctival flap coverage and so on. (Int Rev Ophthalmol, 2022, 46: 247-252)