摘要血管生成素(angiopoietin，Ang)作为促血管生成因子影响视网膜血管的生成与重塑，进一步影响黄斑部正常功能，Ang在湿性年龄相关性黄斑变性(wet age－related macular degeneration，wAMD)的发生发展进程中扮演关键角色，是目前的研究热点。研究表明Ang通过调控血管稳定性、内皮细胞增生及新生血管形成而影响wAMD的发生发展。基于此作用机制，研究血管生成素靶点相关的拮抗药物，为wAMD的治疗提供了新的方向和手段。

abstractsAs another pro-angiogenic factor, angiopoietin plays a key role in the development of Wet age-related macular degeneration (wAMD), and become a hot research topic at present. Studies have demonstrated that angiopoietins influence the pathogenesis and progression of wAMD by modulating vascular stability, endothelial cell proliferation, and neovascularization. Based on this mechanistic understanding, investigating angiopoietin-targeted antagonists has provided novel therapeutic avenues for wAMD treatment.