换一批HGF/c-Met通路及其与肝癌和胆管癌的相关研究
Study in HGF/c-Met pathway and its association with hepatocellular carcinoma and cholangiocarcinoma
摘要肝细胞生长因子及其受体(HGF/c-Met)通路的过度激活在肿瘤的演进过程中起到非常重要的作用.研究证实HGF/c-Met在肝癌及胆管癌中呈高表达,直接或间接参与肿瘤的发生、侵袭和转移过程,且与预后有重要关系.近年来,针对该通路抑制剂的研发已成为抗肿瘤药物的研究热点.
更多相关知识
abstractsOver-activation of HGF/c-Met plays an important role in the evolution process of tumor. It has been demonstrated HGF/c-Met is overexpressed in hepatocellular carcinoma and cholangiocarcinoma, and it participates directly or indirectly in the progress of tumor genesis, invasion and metastasis, as well as has significantly correlation with prognosis. Recently, blocking HGF/c-Met pathway to prevent tumor development and metastasis has become a focus in anti-tumor studies.
More相关知识
关键词
肝细胞生长因子受体蛋白质酪氨酸激酶类肝肿瘤胆管肿瘤Hepatocyte growth factorReceptor protein-tyrosine kinasesLiver neoplasmsBile duct neoplasms
主题词
肝肿瘤(Liver Neoplasms)胆管肿瘤(Bile Duct Neoplasms)研究(Research)肝细胞生长因子(Hepatocyte Growth Factor)受体蛋白质酪氨酸激酶类(Receptor Protein-Tyrosine Kinases)
分类号
R73-37
栏目名称
DOI
10.3760/cma.j.issn.1673-422X.2008.10.020
发布时间
2008-12-22（万方平台首次上网日期，不代表论文的发表时间）
- 浏览280
- 被引5
- 下载12
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
