摘要目的 探讨成纤维细胞生长因子(FGF-2)和人端粒酶逆转录酶(hTERT)在非小细胞肺癌( NSCLC)组织中的表达及其临床意义,初步评价两者在NSCLC发生、发展中的作用及其意义,以及两者之间的相关性.方法 应用免疫组织化学SP法分析90例NSCLC组织、20例非肺癌肺组织中FGF-2和hTERT蛋白的表达水平,并分析两者的表达与临床病理特征的关系.结果 NSCLC组织中FGF-2和hTERT阳性率分别为66.7％和75.6％,显著高于非肺癌肺组织(P＜0.01),FGF-2和hTERT阳性表达与淋巴结转移、临床分期密切相关(P＜0.01),与年龄、性别、病理分型无关(P＞0.05).两者在NSCLC中的表达呈显著正相关(P＜O.01).结论 FGF-2与hTERT蛋白在NSCLC组织中的表达对NSCLC的发生发展中具有重要作用,可以作为NSCLC预后等生物学行为的重要参考指标.

abstractsObjective To investigate the expression and clinical significance of fibroblast growth factor-2 (FGF-2) and human teclomerase reverse transcriptase (hTERT) in non-small cell lung cancer (NSCLC) tissues and analyze the correlation between them.Methods The expression of FGF-2 and hTERT were detected by immunohistochemistry in 90 NSCLC tissues and 20 non-lung carcinoma tissues.The correlation between the expression and clinicopathological features was also analyzed.Results The positive expressions of FGF-2(66.7％ ) and hTERT (75.6％) in NSCLC tissues were significantly higher than that in nonlung carcinoma tissues (15％ and 20％,respectively),P ＜0.01.The expression of FGF-2 and hTERT were significantly related to TNM stages and lymph node metastasis (P ＜ 0.01 ),but not to histological types,sex and age of NSCLC patients ( P ＞ 0.05 ).A positive correlation was found between the expressions of FGF-2 and hTERT in NSCLC(P ＜ 0.01 ).Conclusion The expression of FGF-2 and hTERT in NSCLC,which can be regarded as important references for prognosis of NSCLC,play important roles in the initiation and development of NSCLC.