摘要核糖体由核糖体蛋白和核糖体RNA组成,是蛋白质生物合成的重要场所.核糖体蛋白参与蛋白质的翻译过程,核糖体蛋白和核糖体RNA的表达紊乱将激活核糖体蛋白的核糖体外功能,该功能在肿瘤的发生发展过程中发挥重要作用.核糖体蛋白有望作为生物标志物或治疗靶点用于肿瘤的早期诊断和治疗中.
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abstractsThe ribosome composed of ribosomal RNA and ribosomal proteins is well documented to be an important organelle for protein synthesis.Ribosomal proteins play crucial roles in protein translation.The dysregulation of ribosomal proteins and ribosomal RNA expression activates ribosomal proteins' extraribosomal functions which is believed to play important roles in the tumorigenesis.It is possible that ribosomal proteins may serve as biomarkers or promising targets for the early diagonosis and therapy of tumor diseases.
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