摘要目的 探讨儿童、成人使用痰热清注射液出现药物不良反应(ADR)的差异,指导痰热清的合理应用.方法 采用回顾性研究方法,从甘肃省第二附属人民医院药品ADR监测中心收集2010年1月至2012年10月的ADR事件报告表,筛选出痰热清ADR报告表,分别统计分析痰热清ADR的儿童、成人数.结果 共有603例儿童使用痰热清,其中5例出现ADR(0.83％)；4395例成人使用了痰热清,4例出现ADR (0.09％).两组比较差异有统计学意义(x2=16.07,P＜0.05).无论是成人还是儿童,男性ADR发生率均高于女性,超敏反应为常见的ADR.结论 儿童使用痰热清发生ADR率明显高于成人,应慎重、合理应用.

abstractsObjective To analyze the differences of adverse drug reactions between children and adults caused by Tanreqing injection,and provide reasonable application of Tanreqing injection.Methods Retrospective research method were adopted to screen out the adverse drug reaction reports caused by Tanreqing injection from drug ADR reports of Drug ADR Monitoring Center affiliated to the Second People's Hospital of Gansu Province from January 2010 to October 2012.Figures of children and adults who used Tanreqing injection were analyzed separately.Results A total of 603 children used Tanreqing injection,among which 5 children appeared ADR (0.83％).A total of 4395 adult used of Tanreqing injection,among which 4 appeared in ADR (0.09％).There was statistical difference between the two groups (x2 =16.07,P＜ 0.05) The incidence rate of ADR in males was more than females either in the adults or in children.Hypersensitivity was the most common ADR.Conclusion ADR of Tanreqing injection in Children was significantly higher than adults.Tanreqing injection should be used carefully and rationally.