痰瘀同治法治疗心血管疾病的研究进展
Research progress in treating cardiovascular diseases with the principle of treating phlegm and stasis together
摘要综述近年痰瘀同治法治疗心血管疾病的临床及作用机制研究文献,认为"痰" "瘀"是心血管疾病发生发展的关键因素。此法多用于治疗心绞痛、急性冠脉综合征、高血压、高脂血症,可改善心肌缺血、抗心肌细胞凋亡、改善血管内皮功能、调节炎性细胞因子水平、改善心肌能量代谢、降低心肌损伤标志物水平。目前缺少大规模RCT,有效复方的有效成分及作用机制尚不清楚,机制研究缺少中医特色。
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abstractsThis paper reviews the recent literatures about the clinical and mechanism researches on the treatment of cardiovascular diseases with the principles of treating phlegm and blood stasis together, which showed that phlegm and blood stasis are the key factors for the occurrence and exacerbation of cardiovascular diseases. This method is often used to treat angina pectoris, acute coronary syndrome, hypertension and hyperlipidemia, which could improve the condition of myocardial ischemia, resist myocardial cell apoptosis, improve vascular endothelial function, regulate the level of inflammatory cytokines, improve myocardial energy metabolism and reduce the level of myocardial injury markers. However, there still lacks of large-scale RCT, the effective components and mechanism of effective compound are not clear and the mechanism research lacks TCM characteristics.
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