检索历史 清除

目的 通过研究重症急性胰腺炎(SAP)患者血清二胺氧化酶(DAO)水平变化,探讨DAO在SAP病情严重程度及胃肠道功能障碍程度评估中的作用.方法 选取安徽医科大学第二附属医院急诊科2012年1月至2013年12月收治的56例发病3d内收至入院的SAP患者,入院时抽取血清二胺氧化酶(DAO)标本,同时进行急性生理及慢性健康状况评分Ⅱ(APACHEⅡ)、CT严重度指数(CTSI)及胃肠功能障碍程度评分,并在相应时间点检测患者血清降钙素原(PCT),将血清DAO与这四者进行相关性分析.结果 发现入院时,SAP患者血清DAO水平越高,其相对应的血清PCT浓度(r=0.516,P＜0.01)、APACHEⅡ(r=0.631,P＜0.01)、CTIS(r =0.640,P＜0.01)、胃肠道功能障碍程度(r=0.730,P＜0.01)也越高,血清DAO与其四者均呈正相关.结论 血清DAO在评估SAP患者胃肠功能障碍及疾病严重程度中有一定的预示作用.

Objective To study the change of serum diamine oxidase (DAO) level in patients with severely acute pancreatitis (SAP) in order to explore the role of DAO in assessing the severity of SAP and the magnitude of gastrointestinal dysfunction.Methods From January 2012 through December 2013,56 SAP patients with 33 male and 23 female and average age (45-± 14) years admitted within 3 days after onset were enrolled for this study.At admission,serum diamine oxidase (DAO) was detected,and APACHE Ⅱ score,computed tomography severity index (CTSI) score and Balthazar grading and gastrointestinal dysfunction score were calculated.And at the corresponding time,serum procalcitonin (PCT) was detected.The correlations between serum DAO level and 4 other markers were analyzed.Results The high level of serum DAO was found at admission in SAP patients correlating positively with serum PCT concentrations (r =0.516,P＜ 0.01),APACHE Ⅱ score (r =0.631,P＜ 0.01),CTIS score (r=0.640,P ＜ 0.01),and the degree of gastrointestinal dysfunction (r =0.730,P ＜ 0.01).Conclusions The role of serum DAO in assessing the severity of SAP and magnitude of gastrointestinal dysfunction in SAP patients is really valid.