摘要目的 比较新生儿与婴幼儿阶段体外循环下手术治疗大型VSD的手术过程和近期预后,探讨新生儿期行VSD修补术的可行性.方法 选择2010年10月至2012年9月在北京军区总医院附属八一儿童医院NICU住院并出现充血性心力衰竭症状的16例VSD新生儿为观察组,全身麻醉体外循环下行VSD修补术；随机选择同期于儿童心脏科住院并择期行VSD修补术的婴幼儿18例为对照组.对2组患儿术前一般资料、体外循环时间、阻断时间、术中乳酸水平、术后机械通气时间、监护室停留时间及临床预后进行比较分析.结果 观察组患儿体质量[(3.69±0.72) kg]低于对照组[(8.27±3.39)kg],差异有统计学意义(P＜0.01).2组患儿在VSD直径和性别构成上差异无统计学意义(P＞0.05).2组患儿术中体外循环时间和主动脉阻断时间比较差异无统计学意义(P均＞0.05).观察组术中乳酸水平[(2.76±1.12) mmol/L]显著高于对照组[(1.65±0.34) mmol/L],差异有统计学意义(P＜0.01)；观察组机械通气时间与监护室停留时间分别为(3.69±1.66)d和(9.75±3.44)d,均显著长于对照组[(2.00±0.89)d和(6.17±1.98)d],差异有统计学意义(P均＜0.01).2组患儿的近期预后无差异,全部患儿均顺利出院.结论 新生儿期出现呼吸急促、喂养困难等充血性心力衰竭症状的VSD患儿在体外循环下行VSD修补术是安全可行的.

abstractsObjective To evaluate the feasibility and safety on closing ventricular septal defects (VSDs) under cardiopulmonary bypass(CPB) in neonatal patients with VSD and congestive heart failure.Methods From Oct.2010 to Sep.2012,16 newborn infants with VSD and congestive heart failure in Neonatal Intensive Care Unit(NICU),the Bayi Children's Hospital Affiliated to Beijing Military General Hospital,were selected as the observed group,VSD repair operation was done under CPB.As the control group,18 patients in Pediatrical Cardiac Surgical Department were randomly selected in the same period in hospital,and selective VSD repair operations were done under CPB.Between the 2 groups,demographics(body weight,gender,VSD diameter),clinical characteristics (CPB time,aortic crossclamp time) and early outcomes were compared.Results For the diameter of VSD and gender,there were no significant difference between the 2 groups (P ＞ 0.05).For the body weight,the patients in control group [(8.27 ± 3.39) kg] were more heavier than those in observed group [(3.69 ± 0.72) kg] (P ＜ 0.01).In the operation period,there were no significant differences in CPB time and aortic crossclamp time between 2 groups(all P ＞ 0.05).The lactate value of the patients in observed group [(2.76 ± 1.12) mmol/L] was significantly higher than that in control group [(1.65 ±0.34) mmol/L] (P ＜ 0.01).At the same time,the ventilation time [(3.69 ± 1.66) days] and PICU stay [(9.75 ± 3.44) days] were significantly longer than those in control group[(2.00 ±0.89) days and (6.17 ± 1.98) days] (all P ＜ 0.01).All the patients in the 2 groups discharge out of the hospital,there was no significant difference in outcome.Conclusions The newborns with VSD and congestive heart failure in NICU,can be not improved after the medical management,then closing the VSD is feasible and safe under CPB.