Clarithromycin resistance in Helicobacter pylori and its clinical relevance
篇首: TRODUCTIONThe macrolide clarithromycin has emerged as the most important antibiotic in combined therapy for eradication of H. Pylori infection[1,2]. However, concerns about increasing clarithromycin resistance in H. Pylori and its impact on the efficacy of eradication therapy have been raised since its widespread acceptance in H. Pylori therapy[3,4]. Here, we sought to review the geographic prevalence of clarithromycin resistance in H. Pylori and its molecular mechanisms, and assess the clinical relevance of clarithromycin resistance.
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