换一批
换一批Cloning and identification of NS5ATP2 gene and its spliced variant transactivated by hepatitis C virus non-structural protein 5A
摘要：
AIM: To clone, identify and study new NS5ATP2 gene and its spliced variant transactivated by hepatitis C virus nonstructural protein 5A.METHODS: On the basis of subtractive cDNA library of genes transactivated by NS5A protein of hepatitis C virus, the coding sequence of new gene and its spliced variant were obtained by bioinformatics method. Polymerase chain reaction (PCR)was conducted to amplify NS5ATP2 gene.RESUJLTS: The coding sequence of a new gene and its spliced variant were cloned and identified successfully.CONCLUSION: A new gene has been recognized as the new target transactivated by HCV NS5A protein. These results brought some new clues for studying the biological functions of new genes and pathogenesis of the viral proteins.
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作者单位：
Department of Infectious Disease, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
[1]
Gene Therapy Research Center, Institute of Infectious Diseases, 302 Hospital of PLA, 100 Xisihuanzhong Road, Beijing 100039, China
[2]
期刊：
《世界胃肠病学杂志(英文版)》2004年10卷12期 1735-1739页
SCIMEDLINEISTIC
分类号：
R5
栏目名称：
VIRAL HEPATITIS
发布时间：
2006-07-31
基金项目：
国家自然科学基金
中国研究与发展基金
the Start-up for Students Studying Overseas of PLA
国家科技攻关项目
国家科研项目
Research and Development Foundation of PLA
国家青年科研项目
国家科研项目
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